唐娟副教授
个人简介：
博士，副教授，硕士生导师。主要从事环境毒理学相关研究。江苏省环境诱变剂学会第一届青年委员会委员，南通医学会妇科内分泌学分会会员。
近5年来，主持国家自然科学基金青年、江苏省高校自然科学研究面上项目、南通市科技计划项目。以第一作者和通讯作者在ACS Nano、Environmental pollution、Ecotoxicology and Environmental Safety、Chemosphere、Food and Chemical Toxicology等杂志发表SCI论文16篇，中文核心期刊1篇。
招生方向：卫生与环境卫生学、卫生毒理学
代表论文：
1.Juan Tang#, Lian Li, Chengmin Li, Jie Wu, Yu Sun, Genlin Wang(*), Upregulation of HO-1 with Haemin Alleviates LPS Stimulated Pro-inflammatory Responses Through Downregulation of p38 Signalling Pathways in Rat Liver. Scandinavian journal of immunology, 2015, 82(5), 443-451.
2.Juan Tang#, Chengmin Li, Lian Li, Jie Wu, Genlin Wang*, Changes in expression and production of heme oxygenase-1 in rats with acute liver injury induced by lipopolysaccharide, The Journal of Toxicological Sciences, 2016, 41(4): 469-477.
3.Juan Tang#, Meiyan Song, Gen Watanabe, Kentaro Nagaoka, Xiaoli Rui, Chunmei Li*, Effects of 4-nitrophenol on expression of the ER-α and AhR signaling pathway-associated genes in the small intestine of rats. Environmental Pollution, 2016, 216, 27-37.
4.Juan Tang#, Ping Hu, Yansen Li, Tin-Tin Win-Shwe, Chunmei Li(*), Ion Imbalance Is Involved in the Mechanisms of Liver Oxidative Damage in Rats Exposed to Glyphosate, Frontiers in Physiology, 2017, 8:01083.
5.Juan Tang#, Xiuying Jia, Nana Gao, Yingzhu Wu, Zhengquan Liu, Xiangjun Lu, Qiongxia Du, Jianbo He, Ning Li, Bin Chen, Jinxiao Jiang, Wenli Liu, Ying Ding, Weiqin Zhu, Hangjun Zhang*, Role of the Nrf2-ARE pathway in perfluorooctanoic acid (PFOA)-induced hepatotoxicity in Rana nigromaculata, Environmental pollution, 2018, 238, 1035-1043.
6.Hangjun Zhang#, Wenli Liu, Bin Chen, Jianbo He, Feifei Chen, Xiaodong Shan, Qiongxia Du, Ning Li, Xiuying Jia, Juan Tang*, Differences in reproductive toxicity of TBBPA and TCBPA exposure in male Rana nigromaculata, Environmental pollution, 2018, 243, 394-403.
7.Juan Tang#, Xiangjun Lu, Feifei Chen, Xueping Ye, Dongren Zhou, Julin Yuan, Jianbo He, Bin Chen, Xiaodong Shan, Jinxiao Jiang, Wenli Liu, Hangjun Zhang*. Effects of Perfluorooctanoic Acid on the Associated Genes Expression of Autophagy Signaling Pathway of Carassius auratus Lymphocytes in Vitro. Frontiers in Physiology, 2018, 9:1748. (SCI, 二区, IF5= 4.180).
8.Juan Tang#, Xiangjun Lu, Bin Chen, Enqi Cai, Wenli Liu, Jinxiao Jiang, Feifei Chen, Xiaodong Shan, Hangjun Zhang*. Mechanisms of silver nanoparticles-induced cytotoxicity and apoptosis in rat tracheal epithelial cells.The Journal of Toxicological Sciences,2019, 44(3): 155-165.
9.Juan Tang,Wenxia Bu,Wenxuan Hu,Zixuan Zhao,Lei Liu,Chao Luo,Rui Wang,Susu Fan,Shali Yu,Qiyun Wu,Xiaoke Wang,Xinyuan Zhao. Ferroptosis Is Involved in Sex-Specific Small Intestinal Toxicity in the Offspring of Adult Mice Exposed to Polystyrene Nanoplastics during Pregnancy. ACS Nano, 2023,17(3):2440-2449.
10. Shali Yu#, Ziyang Zhang#, Ziyu Qin, Meijun Liu, Xiaoye Zhao, Yulan Cheng, Peng Xue, Xiaoke Wang, Lin Chen, Qiyun Wu, Linling Ju*and Juan Tang*. Prenatal diesel exhaust exposure alters hippocampal synaptic plasticity in offspring. 2024, Aging, 16(5):4348-4362
11. Xiangdong Wang#, Rui Wang#, Zeyao Zhang, Chao Luo, Zixuan Zhao, Junpu Ruan, Rongrong Huang, Hongbing Zhang, Qiyun Wu, Shali Yu, Juan Tang*andXinyuan Zhao*. Level-specific associations of urinary antimony with cognitive function in US older adults from the National Health and Nutrition Examination Survey 2011-2014. BMC Geriatrics,2022, 22:663.
12.Runzhi Hu, Chenjuan Yao, Yanli Li, Jianhua Qu, Shali Yu, Yu Han, Gang Chen*, Juan Tang*,and Haiyan Wei*. Polystyrene nanoplastics promote CHIP-mediated degradation of tight junction proteins by activating IRE1a/XBP1s pathway in mouse Sertoli cells. Ecotoxicology and Environmental Safety2022, 248:114332.
13.Lulu Gao, Xiangdong Wang, Xuehai Wang, Fengxu Wang, Jinhui Liu*, Juan Tang*and Jinfeng Ji*. A prognostic model and immune regulation analysis of uterine corpus endometrial carcinoma based on cellular senescence. Frontiers in Oncology. 2022, 12:1054564.
14. Aiyi Sui, Chenjuan Yao, Yanhong Chen, Yanli Li, Shali Yu, Jianhua Qu, Haiyan Wei, Juan Tang*and Gang Chen,*Polystyrene nanoplastics inhibit StAR expression by activating HIF-1α via ERK1/2 MAPK and AKT pathways in TM3 Leydig cells and testicular tissues of mice. Food and Chemical Toxicology. 2023, 173:113634.
15.Xiaoke Wang, Zixuan Zhao, Xin Wang, Wenxuan Hu, Chao luo, Xiuyu Chu, Muzhou Qian, Rui Wang, Shali Yu, Qiyun Wu, Juan Tang*and Xinyuan Zhao*. Effects of polystyrene nanoplastic gestational exposure on mice. Chemosphere. 2023, 138255.
16.Xinyi Ma, Mengna Jiang, Wenqian Ji, Mengjiao Yu, Can Tang, Kai Tian, Zhengnan Gao, Liling Su, Juan Tang* and Xinyuan Zhao*. The role and regulation of SIRT1 in pulmonary fibrosis. Molecular Biology Reports, 2024, 51(1):338.
17.步文霞;赵新元;王晓珂;唐娟. 聚苯乙烯纳米塑料的生物学效应及其毒性机制研究进展. 环境与职业医学. 2023, 40(6).
科研项目：
1. 国家自然科学基金委员会, 青年科学基金项目, 82203993, SIRT1下调介导线粒体自噬障碍在纳米塑料诱导肺纤维化中的作用及机制, 2023-01-01至2025-12-31, 30万元, 在研, 主持
2. 江苏省教育厅, 厅级, 江苏省高校自然科学研究面上项目, 22KJB330003, 纳米塑料通过下调SIRT1诱导线粒体自噬障碍及肺纤维化的分子机制, 2022-07至2024-06, 5万元, 结题, 主持
3. 南通市科技局, 市级, 市科技项目, JC12022086, 铁死亡在四氯双酚A诱导精细胞死亡中的作用及调控机制, 2022-7至2024-06, 3万元, 结题, 主持
4. 国家自然科学基金委员会, 地区科学基金项目，82360641，锑暴露调控PHB2诱导肺泡上皮细胞线粒体损伤致肺纤维化作用及机制，2024-01 至 2027-12，32万元，在研，参与
5. 国家自然科学基金委员会, 面上项目, 21876037, 微囊藻毒素干扰黑斑蛙性别分化和性激素合成转化的分子机制, 2019-01-01至2022-12-31, 66万元, 结题, 参与
6. 南通市科技局, 市科技项目, JC2020042, 基于神经元铁死亡探讨锑的神经毒性与机制, 2020-10 至 2022-09, 3万元, 结题, 参与
获得奖项：
青年教师讲课比赛，校级，三等奖
