诸葛祥凯（邮箱：zhugexk@ntu.edu.cn）

个人简介：

诸葛祥凯，博士，1988年生，校聘教授，硕士生导师。长期从事病原微生物感染与防控研究工作，致力于致病性大肠埃希菌、沙门菌和肺炎克雷伯菌等细菌的致病机制和食源性感染潜力研究，重点探究病原微生物与免疫细胞的分子互作机制，以及细菌胞外囊泡（EVs）作为广谱疫苗或疫苗载体应用的技术创新研究，为有效防控致病菌感染提供理论依据和技术手段。以第一和通讯作者，在医学微生物权威期刊PLoS Pathogens和传染病高水平期刊发表致病菌分子流行病学、感染机制和防控技术创新为主题等创新性研究SCI论文二十余篇。先后主持国家重点研发计划课题、江苏省重点研发计划-重点项目、国家自然科学基金项目等国家或省部级项目。

招生方向：预防医学

代表论文：

1. Zhongxing Wang, Rui Chen, Fufang Xia, Min Jiang, Dongyu Zhu, Yuting Zhang, Jianjun Dai*, Xiangkai Zhuge*(2023) ProQ binding to small RNA RyfA promotes virulence and biofilm formation in avian pathogenic Escherichia coli. Veterinary Research 54:109.

2. Zhongxing Wang, Dongyu Zhu, Yuting Zhang, Fufang Xia, Jiaying Zhu, Jianjun Dai*; Xiangkai Zhuge *（2023）Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling. Microbial Cell Factories, 22(1).

3. Min Jiang, Zhongxing Wang, Fufang Xia, Zhe Wen, Rui Chen, Dongyu Zhu, Min Wang, Xiangkai Zhuge*, Jianjun Dai* (2022) Reductions in bacterial viability stimulate the production of Extra-intestinal Pathogenic Escherichia coli (ExPEC) cytoplasmcarrying Extracellular Vesicles (EVs). PLoS Pathog 18(10): e1010908.

4. Fufang Xia; Min Jiang; Zhe Wen; Zhongxing Wang; Min Wang; Yudian Xu; Xiangkai Zhuge*; Jianjun Dai*; Complete genomic analysis of ST117 lineage extraintestinal pathogenic Escherichia coli (ExPEC) to reveal multiple genetic determinants to drive its global transmission: ST117 E. coli as an emerging multidrug‐resistant foodborne ExPEC with zoonotic potential, Transboundary and Emerging Diseases, 2022, 69(6): 3256-3273

5. Zhongxing Wang; Zhe Wen; Min Jiang; Fufang Xia; Min Wang; Xiangkai Zhuge*; Jianjun Dai*; Dissemination of virulence and resistance genes among Klebsiella pneumoniae via outer membrane vesicle: An important plasmid transfer mechanism to promote the emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae, Transboundary and Emerging Diseases, 2022, 69(5): 2661-2676

科研项目：

主持国家重点研发计划课题、江苏省重点研发计划-重点项目、国家自然科学基金项目等国家或省部级项目。