个人简介：
于骏，南通大学高层次引进人才，校聘教授，副研究员、独立PI，硕士研究生导师，江苏高校“青蓝工程”培养对象，主要从事生殖医学相关的临床和基础研究。
现为多家国家级/省级学术团体委员/青年委员，主持/参与国家级及省市级项目十余项，已发表SCI论文30余篇（累积影响因子超过250，引用超过600余次），包括中科院一区Top期刊论文或IF>10分论文8篇，以及中科院二区论文9篇，代表作发表于Nature Communications、Redox Biology、Aging Cell、Human Molecular Genetics、Development、FASEB Journal、Cell Proliferation、Cell Death Disease等杂志，授权国家发明专利2项。目前担任Gene、Journal of Hazardous Materials、Microbiome、Cell Death Discovery、Journal of Genetics and Genomics等多家SCI杂志审稿人。
教育经历：
1. 2011/09–2016/07，南京医科大学，生殖医学国家重点实验室，博士，导师：沙家豪、周作民 教授；
2. 2012/09–2016/07，浙江大学生命科学研究院联合培养，联合培养导师：佟超 教授；
3. 2006/09–2011/07，南京医科大学，第一临床医学院，临床医学专业，学士。
学术任职和人才计划：
1. 中国妇幼保健协会妇科智能（AI）医学专业委员会青年委员；
2. 中国中药协会女性生殖健康药物研究专业委员会青年委；
3. 江苏省免疫学会基础免疫专业委员会常务委员；
4. 江苏省免疫学会生殖免疫专业委员会委员；
5. 南通市医学会生殖医学分会委员；
6. 中国初级卫生保健基金会关爱男性健康公益基金苏中男科专家委员会常务委员；
7. 江苏高校“青蓝工程”优秀青年骨干教师。
招生方向：生殖毒理、环境暴露物与生殖衰老的调控
代表论文：
1. Jun Yu (#, *), Zhiran Li (#), Yangbo Fu (#), Feiteng Sun (#), Xia Chen, Qiuru Huang, Lei He, Hao Yu, Li Ji, Xinmeng Cheng, Yi Shi, Cong Shen, Bo Zheng (*), Fei Sun (*). Single-cell RNA-sequencing reveals the transcriptional landscape of ND-42 mediated spermatid elongation via mitochondrial derivative maintenance in Drosophila testes. Redox Biol. 2023 Mar 15;62:102671.
2. Xia Chen (#), Yujuan Qi (#), Qiuru Huang (#), Chi Sun (#), Yanli Zheng (#), Li Ji, Yi Shi, Xinmeng Cheng, Zhenbei Li, Sen Zheng, Yijuan Cao(*), Zhifeng Gu(*), Jun Yu(*). Single-cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila. Aging Cell. 2023 Dec 3:e14057.
3. Xiaoke Wang (#), Peiyao Zhou (#), Ziyang Zhang (#), Qiuru Huang (#), Xia Chen, Li Ji, Xinmeng Cheng, Yi Shi, Shali Yu, Juan Tang, Chi Sun (*), Xinyuan Zhao (*), Jun Yu (*). A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis. Free Radic Biol Med. 2023 Sep 2; S0891-5849(23)00614-7.
4. Jun Yu (#, *), Qianwen Zheng (#), Zhiran Li (#), Yunhao Wu (#), Yangbo Fu, Xiaolong Wu, Dengfeng Lin, Cong Shen, Bo Zheng(*), Fei Sun(*). CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes. Cell Death Dis. 2021 May 14;12(5):491.
5. Min Wang, Xia Chen, Yibo Wu, Qianwen Zheng, Wanyin Chen, Yidan Yan, Xiaojin Luan, Cong Shen, Jie Fang(*), Bo Zheng(*), Jun Yu (*). RpS13 controls the homeostasis of germline stem cell niche through Rho1-mediated signals in the Drosophila testis. Cell Prolif. 2020 Sep 8; e12899.
6. Jun Yu (#), Yidan Yan(#), Xiaojin Luan(#), Chen Qiao(#), Yuanyuan Liu(#), Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Qixiang Shao, Xia Chen(*), Bo Zheng(*) and Jie Fang(*). Srlp is crucial for the self-renewal and differentiation of germline stem cells via RpL6 signals in Drosophila testes. Cell Death Dis. 2019 Apr 1; 10 (4): 294.
7. Zhibin Hu(#)(*)，Zheng Li(#)，Jun Yu(#)，Chao Tong(#)，Yuan Lin(#)，Xuejiang Guo(#)，Feng Lu，Jing Dong，Yankai Xia，Yang Wen，Hao Wu，Honggang Li，Yong Zhu，Ping Ping，Xiangfeng Chen，Juncheng Dai，Yue Jiang，Shandong Pan，Peng Xu，Kailing Luo，Qiang Du，Bing Yao，Ming Liang，Yaoting Gui，Ning Weng，Hui Lu，Zhuqing Wang，Fengbin Zhang，Xiaobin Zhu，Xiaoyu Yang，Zhou Zhang，Han Zhao，Chenliang Xiong，Hongxia Ma，Guangfu Jin，Feng Chen，Jianfeng Xu，Xinru Wang，Zuomin Zhou，Zi-Jiang Chen(*)，Jiayin Liu(*)，Hongbing Shen，Jiahao Sha(*). Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun. 2014, 5:3857.
8. Jun Yu (#), Cong Shen (#), Meng Lin (#), Xia Chen (#), Xiuliang Dai, Zhiran Li, Yunhao Wu, Yangbo Fu, Jinxing Lv, Xiaoyan Huang (*), Bo Zheng (*), Fei Sun (*). BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b/β-catenin signaling. Int J Biol Sci. 2022; 18(7): 2807-2820.
9. Hongliang Cui(#), Qiuru Huang(#), Jiaxin Li(#), Peiyao Zhou(#), Zihan Wang, Jiaying Cai, Chenrui Feng, Xiaonan Deng, Han Gu, Xuxin He, Juan Tang, Xiaoke Wang, Xinyuan Zhao(*), Jun Yu(*), Xia Chen(*). Single-cell RNA sequencing analysis to evaluate antimony exposure effects on cell-lineage communications within the Drosophila testicular niche. Ecotoxicol Environ Saf. 2024 Jan 6;270:115948.
10. Jun Yu (#, *), Jinfu Xu (#), Hong Li (#), Pengfei Wu, Shiyao Zhu, Xiaoyan Huang, Cong Shen, Bo Zheng (*), Wenqing Li (*). Gold nanoparticles retrogradely penetrate through testicular barriers via Sertoli-cells mediated endocytosis/exocytosis and induce immune response in mouse. Ecotox Environ Safe. 2023
11. Jun Yu(#)(*), Xiaojin Luan(#), Yidan Yan(#), Chen Qiao(#), Yuanyuan Liu(#), Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Binghai Chen, Bo Zheng(#), Xia Chen(#), and Jie Fang(*). Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in Drosophila. FASEB J. 2019 Jul; 33 (7): 8125-8137.
12. Jun Yu(#)，Xiang Lan(#)，Xia Chen(#)，Chao Yu，Yiwen Xu，Yujuan Liu，Lingna Xu，Heng-Yu Fan，Chao Tong(*). Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Development. 2016, 143 (16): 2930-2945.
13. Jun Yu(#)，Hao Wu(#)，Yang Wen(#)，Yujuan Liu(#)，Tao Zhou，Bixian Ni，Yuan Lin，Jing Dong，Zuomin Zhou，Zhibin Hu(*)，Xuejiang Guo(*)，Jiahao Sha(*)，Chao Tong(*). Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Hum Mol Genet. 2015, 24 (5):1493-1503.
14. Qiuru Huang (#), Xia Chen (#), Hao Yu (#), Li Ji, Yi Shi, Xinmeng Cheng, Hao Chen (*), Jun Yu (*). Structure and molecular basis of spermatid elongation in the Drosophila testis. Open Biology. 2023.
15. Jun Yu (#), Yangbo Fu (#), Zhiran Li (#), Qiuru Huang (#), Juan Tang, Chi Sun, Peiyao Zhou, Lei He, Feiteng Sun, Xinmeng Cheng, Li Ji, Hao Yu, Yi Shi, Zhifeng Gu (*), Fei Sun (*), Xinyuan Zhao (*). Single-cell RNA sequencing reveals cell landscape following antimony exposure during spermatogenesis in Drosophila testes. Cell Death Discov. 2023 Mar 9;9(1):86.
16. Zhiran Li (#), Yunhao Wu (#), Yangbo Fu (#), Xia Chen (#), Xi Zhao, Xiaolong Wu, Yajuan Lu, Hui He, Cong Shen, Bo Zheng (*), Jun Yu (*), Fei Sun (*). Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ mediated pre-initiation complex. Stem Cell Res Ther. 2022 Jul 26;13(1):351.
17. Jun Yu (#), Yibo Wu (#), Hong Li (#), Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang (*), Bo Zheng (*), Fei Sun (*). BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway. Front Cell Dev Biol. 2021 Apr 13;9:665089.
18. Qianwen Zheng, Xia Chen, Chen Qiao, Min Wang, Wanyin Chen, Xiaojin Luan, Yidan Yan, Cong Shen, Jie Fang, Xing Hu, Bo Zheng (*), Yibo Wu (*), Jun Yu (*). Somatic CG6015 mediates cyst stem cell maintenance and germline stem cell differentiation via EGFR signaling in Drosophila testes. Cell Death Discov. 2021 Apr 6;7(1):68.
19. Wanyin Chen, Xiaojin Luan, Yidan Yan, Min Wang, Qianwen Zheng, Xia Chen(*), Jun Yu(*), Jie Fang(*). CG8005 Mediates Transit-Amplifying Spermatogonial Divisions via Oxidative Stress in Drosophila Testes. Oxid Med Cell Longev. 2020 Oct 27; 2020: 2846727.
20. Xia Chen (#), Qianwen Zheng (#), Li Ji (#), Yanyan Zhuang (#), Hao Yu, Xinmeng Cheng, Yun Han, Jinxing Lv, Bo Zheng (*), Yanli Zheng (*), Jun Yu (*). Quantitative proteomics and functional analysis identified novel targets for missed abortion. Exp Cell Res. 2022 Aug 15;417(2):113216.
21. Meng Lin (#), Jinxing Lv (#), Dan Zhao (#), Siyu Liu, Jinfu Xu, Yangyang Wu, Fuxin Wang, Jun Zhang, Bo Zheng, Cong Shen (*), Xie Guan (*), Jun Yu (*), Xiaoyan Huang (*). MRNIP is essential for meiotic progression and spermatogenesis in mice. Biochem Biophys Res Commun. 2021 Apr 23;550:127-133.
22. Tingting Gao(#), Meng Lin(#), Binbin Shao(#), Qiao Zhou(#), Yufeng Wang(#), Xia Chen, Dan Zhao, Xiuliang Dai, Cong Shen, Hongbo Cheng, Shenmin Yang, Hong Li, Bo Zheng(*), Xingming Zhong(*), Jun Yu (*), Li Chen(*), Xiaoyan Huang(*). BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells. Cell Cycle. 2020 Aug; 19 (15):1884-1898.
23. Dan Zhao(#), Cong Shen(#) (*), Tingting Gao(#), Hong Li(#), Yueshuai Guo(#), Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang(*), Jun Yu (*), Jun Zhang(*), Bo Zheng(*). Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling. Cell Cycle. 2019 Oct;18 (20): 2800-2813.
24. Cong Shen(#), Jun Yu (#), Xi Zhang, ChenChen Liu, YueShuai Guo, JiaWei Zhu, Ke Zhang, Yi Yu, TingTing Gao, ShenMin Yang, Hong Li, Bo Zheng(*), XiaoYan Huang(*). Strawberry Notch 1 (SBNO1) promotes proliferation of spermatogonial stem cells via the noncanonical Wnt pathway in mice. Asian J Androl. 2019;21(4):345-350.
25. Jie Fang(#)(*), Xueke Guo(#), Bo Zheng(#), Wei Han(#), Xia Chen(#), Jiawei Zhu(#), Bing Xie, Jiajia Liu, Xiaojin Luan, Yidan Yan, Zeyu He, Hong Li, Chen Qiao, Jun Yu (*). Correlation between NM23 protein overexpression and prognostic value and clinicopathologic features of ovarian cancer: a meta-analysis. Arch Gynecol Obstet. 2018, 297 (2): 449-458.
26. Cong Shen(#), Ke Zhang(#), Jun Yu(#), Yueshuai Guo(#), Tingting Gao, Yuanyuan Liu, Xi Zhang, Xia Chen, Yi Yu, Hongbo Cheng, Aiyan Zheng, Hong Li(*), Xiaoyan Huang(*), Xufeng Ding(*), Bo Zheng(*). Stromal interaction molecule 1 is required for neonatal testicular development in mice. Biochem Biophys Res Commun. 2018 Oct 12; 504 (4): 909-915.
27. Bo Zheng(#)(*), Jun Yu (#), Yueshuai Guo(#), Tingting Gao, Cong Shen, Xi Zhang, Hong Li(*), Xiaoyan Huang(*). Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice. Reproduction. 2018 Jul;156 (1): 59-69.
28. Cong Shen(#), Jinfu Xu(#), Qiao Zhou(#), Meng Lin, Jinxing Lv, Xi Zhang, Yangyang Wu, Xia Chen, Jun Yu (*), Xiaoyan Huang(*), Bo Zheng(*). E3 ubiquitin ligase ASB17 is required for spermiation in mice. Transl Androl Urol. 2021 Dec;10(12):4320-4332.
29. Xifeng Yin(#), Jun Yu(#), Yang Zhou, Chengyue Wang, Zhimin Jiao, Zhounan Qian, Hao Sun, Binghai Chen(*). Identification of CDK2 as a novel target in treatment of prostate cancer. Future Oncol. 2018, 14 (8): 709-718.
30. Hao Wu(#)，Liwei Sun(#)，Yang Wen(#)，Yujuan Liu，Jun Yu，Feiyu Mao，Ya Wang，Chao Tong，Xuejiang Guo，Zhibin Hu，Jiahao Sha，Mingxi Liu(*)，Laixin Xia(*). Major spliceosome defects cause male infertility and are associated with non-obstructive azoospermia in humans. Proc Natl Acad Sci USA. 2016, 113 (15): 4134-4139.
科研项目：
1. 江苏省自然科学基金面上项目，BK20221376, 2022/07-2025/06, 10万，在研，主持；
2. 南通市基础科学研究计划（青年科技人才创新专项），JC12022006，2022/07-2024/06,，3万，主持；
3. 国家自然科学基金青年项目，31701298，2018/01-2020/12，23万，已结题，主持；
4. 江苏省自然科学基金青年项目，BK20170562，2017/07-2020/06，20万，已结题，主持；
5. 镇江市重点研发计划（社会发展），SH2016028，2016/11-2018/10，5万，已结题，主持；
6. 南京医科大学生殖医学国家重点实验室开放基金，SKLRM-KA201603,2016/11-2018/10，10万元，已结题，主持；
7. 国家自然科学基金委员会，青年项目，81803505，2019/01-2021/12，21万元，在研，参与；
8. 镇江市重点研发计划（社会发展），SH2017013，2017/11-2019/12，3万元，已结题，参与。
