姓名：赵新元
职称：教授 博士生导师任南通市环境毒理学重点实验室常务副主任职业医学与环境毒理学系系主任
电话：051385012912
个人简介
赵新元，男，医学博士，南通大学公共卫生学院副教授，博士生导师，南通市环境毒理学重点实验室常务主任，环境与健康研究团队负责人，职业医学与环境毒理学系系主任，江苏省青蓝工程优秀青年骨干教师。围绕环境污染物毒效应及其机制开展了多年的基础研究。第一完成人获得江苏省高校科学技术研究成果奖一项。近5年来，主持国家自然科学基金面上、国家自然科学基金青年、省自然科学基金面上等项目。以第一作者和通讯作者在ACS Nano、Science of the total environment、Journal of nanobiotechnology、Environmental pollution、Cell death and disease等杂志发表SCI论文50余篇。其中IF>10以上4篇，中科院一区9篇，二区20余篇。
专业研究领域
1. 纳米材料的呼吸毒性研究、重金属的呼吸毒性研究
2. 纳米颗粒物、金属暴露及POPs的呼吸和神经毒理学研究
3. 构建动物模型研究环境颗粒物和重金属对肥胖、糖尿病和非酒精性脂肪肝等慢性病的影响及相关分子机制
4. 人群数据与生信数据分析
专著与论集
《航海医学》编委
《现代分子生物学导论》编委
《现代职业卫生与职业医学》编委
学术论文
1. Xinyuan Zhao#, Saisai Wei#, Zhijian Li, Chen Lin, Zhenfeng Zhu, Desen Sun, Rongpan Bai, Jun Qian, Xiangwei Gao*, Guangdi Chen*, Zhengping Xu*. Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis. Cell death and Disease. 2019, 10:127.
2. Xinyuan Zhao#, Yiming Liu#, Ganlin Zhu, Yuanyuan Liang, Bo Liu, Yifan Wu, Muxi Han, Wenxing Sun, Yu Han, Gang Chen, Junkang Jiang*. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. Science of The Total Environment. 2019, 646(1): 1047-1055.
3. Xinyuan Zhao#,*, Yifan Wu#, Jinlong Li, Dongyu Li, Yang Jin, Piaoyu Zhu, Yingqi Liu, Yin Zhuang, Shali Yu, Weiming Cao, Haiyan Wei, Xiaoke Wang, Yu Han*, Gang Chen*. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology. 2019, 423: 42-53.
4. Xinyuan Zhao#, Yang Jin#, Lijia Yang, Zhengxing Hou, Yingqi Liu, Tianyu Sun, Jiaxin Pei, Jinlong Li, Chenjuan Yao, Xiaoke Wang*, Gang Chen*. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicology Letters. 2018, 296: 73-81.
5. Xinyuan Zhao, Fengjun Xing, Yewen Cong, Yin Zhuang, Muxi Han, Zhiqiang Wu, Shali Yu, Haiyan Wei, Xiaoke Wang*, Gang Chen*. Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells. The International Journal of Biochemistry and Cell Biology. 2017, 93(12): 32-40.
6. Xinyuan Zhao, Lifeng Yin, Yifan Wu, Muxi Han, Yin Zhuang, Yewen Cong, Yiming Liu, Gang Chen, Junkang Jiang*. Manganese induces neuroinflammation via NF-kB/ROS NLRP3 pathway in rat brain striatum and HAPI cells. Molecular & Cellular Toxicology. 2019, 15: 173-183.
7. ZHAO Xinyuan, FANG Wenpan, Lin Chen, Chen Guangdi*. Association of Exposure to Extremely Low Frequency Electromagnetic Fields with Adverse Birth Outcomes. High Voltage Engineering. 2015, 41(4): 1383-1389.
8. Ganlin Zhu#, Yiming Liu#, Ye Zhi, Yang Jin, Jinlong Li*, Weiwei Shi, Yuting Liu, Yu Han, Shali Yu, Junkang Jiang*, Xinyuan Zhao*. PKA- and Ca2+ -dependent p38MAPK/CREB activation protects against manganese-mediated neuronal apoptosis. Toxicology Letters. 2019, 309: 10-19. *corresponding author.
9. Changyue Wu, Yifan Wu, Yang Jin, Piaoyu Zhu, Weiwei Shi, Jinlong Li, Qinyun Wu, Qinglin Zhang*, Yu Han*, Xinyuan Zhao*. Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis. RSC Advances. 2019, 9, 13855-13862. *corresponding author.
10. Man Jiao#, Kaizhi Yin#, Tao Zhang, Changyue Wu, Yan Zhang, Xinyuan Zhao*, Qinyun Wu*. Effects of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death. Chemosphere. 2019, 226: 678-686. *corresponding author.
11. Dongyu Li#, Xinyuan Zhao#, Wei Qin, Hequn Zhang, Yue Fei, Liwei Liu, Ken-Tye Yong, Guangdi Chen*, Ben Zhong Tang*, Jun Qian*. Toxicity Assessment and Long-term Three photon Fluorescence Imaging of Bright AIE Nanodots in Zebrafish. Nano Research. 2016，9(7):1921-1933. # co-first author
12. Chen Lin#, Xinyuan Zhao#, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu*, Xiangwei Gao*. Transcriptional activation of Follistation by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress. Scientific Reports. 2016, Feb 16; 6:21133. # co-first author
13. Li jiang#, Xinyuan Zhao#, Yu Fei, Dongdong Yu, Jun Qian, Jinguang Tong, Guangdi Chen*, Sailing He*. The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution. Scientific Reports. 2016, Apr 28; 6:25111. # co-first author
14. Chunyan Huang#, Xinyuan Zhao#, Yan Lu, Linchi Wang, Yihe Hu, Jun Zhang, Qiaoliang Huang, Gang Chen*. Changes in life expectancy from 2006 to 2015 in Suzhou, East China: contribution of Age- and Cause-specific Mortality. Asia-Pacific Journal of Public Health. 2018, 30(1): 75-84. # co-first author
15. Dongyu Li, Li Xue, Zhenfeng Zhu, Xinyuan Zhao*, Jun Qian*. Graphene oxide nanoparticles for two-photon fluorescence imaging of zebrafish. Optical and Quantum Electronics. 2016, 48(11): 519 *corresponding author.
16. Changyue Wu, Kaizhi Yin, Yan Zhang, Man Jiao, Xinyuan Zhao*, Qiyun Wu*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway. Biomedical and Environmental Sciences. 2019, 32(4): 281-290. *corresponding author.
17. Xiaoke Wang#, Piaoyu Zhu#, Shenya Xu, Yuting Liu, Yang Jin, Shali Yu, Haiyan Wei, Jinlong Li, Qinglin Zhang, Takahiro Hasegawa, Chenjuan Yao, Hiroshi Yoshimura, Qiyun Wu, Xinyuan Zhao*. Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. The International Journal of Biochemistry and Cell Biology. 2019, 114(9).
18. Xiaoke Wang#, Yuxue Yang#, Piaoyu Zhu, Yifan Wu, Yang Jin, Shali Yu, Haiyan Wei, Muzhou Qian, Weiming Cao, Shenya Xu, Yingqi Liu, Gang Chen, Xinyuan Zhao*. Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. Environmental Pollution. 2019, 255:113366. *corresponding author.
19. Liling Su, Longtao Zhu, Zhenchao Liu, Jianyao Lou, Bing Han, Chen Lin, Dongyu Li, Jun Qian, Xinyuan Zhao*, Guangdi Chen*. The decreased permittivity of zebrafish embryos culture medium by magnetic fields did not affect early development of zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 193: 110350. *corresponding author.
20. Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen*, Xinyuan Zhao*. p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation. Journal of nanobiotechnology. 2020, 18:77. *corresponding author.
21. Weiwei Shi, Yanfen Tang, Ye Zhi, Zhijie Li, Shali Yu, Junkang Jiang, Jinfeng Zhu, Jinlong Li, Junkang Jiang, Feng Wang*, Liling Su*, Xinyuan Zhao*. Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity. Science of The Total Environment. 2020, 737: 140252.
22. Ye Zhi, Chunhua Lu, Ganlin Zhu, Zhijie Li, Piaoyu Zhu, Yuting Liu, Weiwei Shi, Liling Su, Junkang Jiang*, Jianhua Qu*, Xinyuan Zhao*. Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain. Neurotoxicology. 2020, 81: 101-108. *corresponding author.
23. Shenya Xu, Zeyun Yang, Ye Zhi, Shali Yu, Tao Zhang, Junkang Jiang, Jun Tang, Hongsen He, Ming Lu, Xiaoke Wang*, Qiyun Wu*, Xinyuan Zhao*. The effects of antimony on Alzheimer’s disease-like pathological changes in mice brain. Science of the Total Environment. Accepted. *corresponding author.
24. Tao Zhang, Yudan Zheng, Man Jiao, Zhi Ye, Shenya Xu, Piaoyu Zhu, Xinyuan Zhao*, Qiyun Wu*. Nuclear Factor-kB Signaling Mediates Antimony-induced Astrocyte Activation. Biomedical and Environmental Sciences. 2021, 34(1): 29-39. *corresponding author.
25. Yudan Zheng, Wenjie Ding, Tao Zhang, Zixuan Zhao, Rui Wang, Zhjie Li, Shali Yu, Jinlong Li, Xinyuan Zhao*, Qiyun Wu*. Antimony-induced astrocyte activation via mitogen-activated protein kinase activation-dependent CREB phosphorylation. Toxicology Letters. 2021, 352: 9-16. *corresponding author.
26. Wenyi Zhang, Ting Chen, Jun Liu, Shali Yu, Lei Liu, Miaosen Zheng, Yifei Liu, Hongbing Zhang*, Tingting Bian*, Xinyuan Zhao*. RAB11F1P1: An Indicator for Tomor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics. Frontiers in Genetics. 2021, 12: 757169. *corresponding author.
26. 王瑞，刘蕾，邱红梅，赵新元*. 纳米二氧化硅影响自噬的机制及其生物学意义的研究进展. 重庆医学，2022，51（5）：874-879. (通讯作者)
27. Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang*, Xinyuan Zhao*. GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis. Ecotoxicology and Environmental Safety. 2022, 234: 113413. *corresponding author.
28. Wenyi Zhang, Pei Xiao, Jiayi Tang, Rui Wang, Xiangdong Wang, Fengxu Wang, Junpu Ruan, Shali Yu, Juan Tang, Rongrong Huang*, Xinyuan Zhao*. m6A Regulator-Mediated Tumor Infiltration and Methylation Modification in Cervical Cancer Microenvironment. Frontiers in Immunology. 2022, 888650. *corresponding author.
29. Li Zeng, Xuehai Wang, Fengxu Wang, Xinyuan Zhao*, Yiqian Ding*. Identification of a Gene Signature of Cancer-Associated Fibroblasts to Predict Prognosis in Ovarian Cancer. Frontiers in Genetics. 2022, 925231. *corresponding author.
30. Chunyan Gu, Chen Lin, Zheng Zhu, Li Hu, Fengxu Wang, Xuehai Wang, Junpu Ruan, Xinyuan Zhao*, Sen Huang*. The IFN-γ-related long non-coding RNA signature predicts prognosis and indicates immune microenvironment infiltration in uterine corpus endometrial carcinoma. Frontiers in Oncology. 2022, 955979. *corresponding author.
31. Xiangdong Wang, Rui Wang, Zeyao Zhang, Chao Luo, Zixuan Zhao, Junpu Ruan, Rongrong Huang, Hongbing Zhang, Qiyun Wu, Shali Yu, Juan Tang*, Xinyuan Zhao*. Level-specific associations of urinary antimony with cognitive function in US older adults from the National Health and Nutrition Examination Survey 2011-2014. BMC Geriatrics. 2022, 955979. *corresponding author.
32. Haixia Tang, Jingsong Shan, Juan Liu, Xuehai Wang, Fengxu Wang, Suping Han*, Xinyuan Zhao*, Jinxiu Wang*. Molecular subtypes, clinical significance, and tumor immune landscape of angiogenesis-related genes in ovarian cancer. Frontiers in Oncology. 2022, 995929. *corresponding author.
33. Weiwei Shi, Wenjie Ding, Zixuan Zhao, Rui Wang, Fengxu Wang, Yanfen Tang, Jinfeng Zhu, Chengcheng Su, Xinyuan Zhao*, Lei Liu*. Peroxidase is a novel potential marker in glioblastoma through bioinformatics method and experimental validation. Frontiers in Genetics, 2022, 990344. *corresponding author.
34. Xiangdong Wang, Pei Xiao, Rui Wang, Chao Luo, Zeyao Zhang, Qiyun Wu, Ye Li, Yali Zhang*, Hongbing Zhang*, Xinyuan Zhao*. Relationships between urinary metals concentions and cognitive performance among U.S. older people in NHANES 2011-2014. Frontiers in Public Health, 2022, 985127. *corresponding author.
35. Erli Gao, Xuehai Wang, Fengxu Wang, Siyuan Deng, Weiyi Xia, Rui Wang, Xiangdong Wang, Xinyuan Zhao*, Haixin Qian*. Systematic Characterization of Expression Patterns and Immunocorrelation of Formin-Like Genes in Breast Cancer. BioMed Research International, 2022, 8577821. *corresponding author.
36. Wenjun Mao, Yun Cai, Danrong Chen, Guanyu Jiang, Yongrui Xu, Ruo Chen, Fengxu Wang, Xuehai Wang, Mingfeng Zheng*, Xinyuan Zhao*, Jie Mei*. Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockage in non-small cell lung cancer. JCI insight, 2022, 7(18): e161940. *corresponding author.
37. Fengxu Wang, Xuehai Wang, Lei Liu, Siyuan Deng, Wenqian Ji, Yang Liu, Xiangdong Wang, Rui Wang, Xinyuan Zhao*, Erli Gao*. Comprehensive analysis of PTPN gene family revealing PTPN7 as a novel biomarker for immuno-hot tumors in breast cancer. Frontiers in Genetics, 2022, 981603. *corresponding author.
38. Wenjie Ding, Zixuan Zhao, Yudan Zheng, Rui Wang, Zeyao Zhang, Ziyang Zhang, Xiangdong Wang, Shali Yu, Lei Liu, Rongrong Huang, Xinyuan Zhao*, Qiyun Wu*. Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway. Ecotoxicology and Environmental Safety. 2022, 234: 113413. *corresponding author.
39. 李志杰，王瑞，刘蕾，于莎莉，江俊康，赵新元*. 抗增殖蛋白2在线粒体中的功能研究进展. 交通医学，2022，36（4）：340-343. (通讯作者)
40. 赵子轩，王晓珂，朱颖，吴启运，赵新元*. POPs调控肝内脂肪酸从头合成相关分子的研究进展. 重庆医学，2022，51（14）：2495-2498. (通讯作者)
41. Hongyu Zhao, Fengxu Wang, Xuehai Wang, Xinyuan Zhao*, Jinfeng Ji*. HPV-related prognostic signature predicts survival in head and neck squamous cell carcinoma. Journal of Oncology. 2022, 7357566. *corresponding author.
42. Xuehai Wang, Fengxu Wang, Weiyi Xia, Siyuan Deng, Hongxiang Zhang, Xinyuan Zhao*. Facts and challenges of immunotherapy in triple-negative breast cancer. Tumor Discovery. 2022, 1(2). *corresponding author.
43. Lingling Hong, Xuehai Wang, Weiming Cui, Fengxu Wang, Weiwei Shi, Shali Yu, Yonghua Luo*, Lixin Zhong*, Xinyuan Zhao*. Construction of a ferroptosis scoring system and identification of LINC01572 as a novel ferroptsis suppressor in lung adenocarcinoma. Frontiers in Pharmacology. 2023, 1098136. *corresponding author.
44. Shuting Meng, Tianye Zhu, Zhiwei Fan, Yulan Cheng, Yanfeng Dong, Fengxu Wang, Xuehai Wang, Deping Dong*, Songtao Yuan*, Xinyuan Zhao*. Integrated signal-cell and transcriptome sequencing analysis develops a metastasis-based risk score system for prognosis and immunotherapy response in uveal melanoma. Frontiers in Pharmacology. 2023, 1138452. *corresponding author.
45. Juan Tang, Wenxia Bu, Wenxuan Hu, Zixuan Zhao, Lei Liu, Chao Luo, Rui Wang, Susu Fan, Shali Yu, Qiyun Wu *, Xiaoke Wang *, Xinyuan Zhao*. Ferroptosis is involved in sex-specific small intestinal toxicity in the offspring of adult mice exposed to polystyrene nanoplastics during pregnancy. ACS Nano. 2023. *corresponding author.
46. Xiaoke Wang, Zixuan Zhao, Xin Wang, Wenxuan Hu, Chao Luo, Xiuyu Chu, Muzhou Qian, Rui Wang, Shali Yu, Qiyun Wu, Juan Tang *, Xinyuan Zhao*. Effects of polystyrene nanoplastic gestational exposure on mice. Chemosphere. 2023, 138255 *corresponding author.
47. Jun Yu, Yangbo Fu, Zhiran Li, Qiuru Huang, Juan Tang, Chi Sun, Peiyao Zhou, Lei He, Feiteng Sun, Xinmeng Cheng, Li Ji, Hao Yu, Yi Shi, Zhifeng Gu*, Fei Sun*, Xinyuan Zhao*. Single-cell RNA sequencing reveals cell landscape following antimony exposure during spermatogenesis in Drosophila testes. Cell death discovery. 2023. 9: 86 *corresponding author.
48. Min Zhao, Jin Wan, Wenzhi Qin, Xin Huang,Guangdi Chen*, Xinyuan Zhao*. A machine learning-based diagnosis modelling of type 2 diabetes mellitus with environmental metal exposure. Computer methods and programs in biomedicine. 2023. 235: 107537 *corresponding author.
49. Xinyuan Zhao#, Tao Zhang#, Yudan Zheng, Zixuan Zhao, Wenjie Ding, Ziyang Zhang, Zeyao Zhang, Man Jiao, Lei Liu, Xiaoke Wang, Rongrong Huang*, Qiyun Wu*. Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation. Journal of agricultural and food chemistry. 2023.
主要科研项目
1. 国家自然科学基金面上项目，82173554，纳米二氧化硅通过下调SIRT1碱化肺泡上皮细胞溶酶体及诱导肺纤维化，2022/01-2025/12，55万，在研，主持。
2. 国家自然科学基金青年项目，81703255，肺泡上皮细胞p62聚集在超细颗粒物诱导肺纤维化中的作用及机制研究，2018/01-2020/12，20万，结题，主持。
3. 江苏省自然科学基金面上项目，SIRT1降解在纳米二氧化硅诱导肺泡上皮细胞溶酶体碱化及肺纤维化中的作用和机制，2020/07-2023/06，10万，在研，主持。
4. 江苏省高校“青蓝工程”，优秀青年骨干教师，2020/05-2023/05，4万，在研。
5. 南通市社会发展科技计划项目，MS12017014-8，靶向加快自噬流在颗粒物诱导肺损伤中的预防作用及机制研究，2017/07-2019/07，4万，结题，主持。
6. 南通市基础科学研究项目，JC2019027，基于Wnt通路评估一种新神经毒物-锑的阿尔茨海默病致病风险， 2019.07-2021.06，3万，结题，主持。
7. 自噬在锑引起A549细胞损伤中的作用及机制，南通大学引进人才项目，2017/04-2019/04，4万，结题，主持。
8. 校级教改课题，基于实践技能导向的《环境卫生学》实验教学改革研究，2018/09-2020/06，0.3万，结题，主持。
9. 南通大学大型仪器设备开放基金，2020年，0.5万，结题，主持。
10. 校级教改课题，《环境卫生学》课程试题库建设项目，2018/01-2018/12，结题，主持。
