赵新元  教授

医学博士，教授，博士生导师，任学院副院长、南通市环境毒理学重点实验室常务副主任。2016年毕业于浙江大学医学院劳动卫生与环境卫生学专业，主要从事环境毒理学相关研究。入选江苏省高校青蓝工程，担任中国毒理学会青年委员、中国环境诱变剂学会致突变专委会青年委员、江苏省预防医学会环境卫生专委会常务委员、江苏省预防医学会职业健康专委会常务委员、南通市医学会生殖医学会副主任委员、南通市医学会中毒分会副主任委员等社会兼职。

第一完成人获得江苏省高校科学技术研究成果奖一项。近5年来，主持国家自然科学基金面上、国家自然科学基金青年、省自然科学基金面上等项目。以第一作者和通讯作者在ACS Nano, Science of the total environment、Journal of nanobiotechnology、Environmental pollution、Cell death and disease等杂志发表SCI论文50余篇，其中中科院一区10篇。授权软件著作权两项。

  实验室链接：南通市环境毒理学重点实验室 (x-mol.com)

招生方向：

卫生与环境卫生学、卫生毒理学

代表论文：

第一作者：

1. Xinyuan Zhao^#, Saisai Wei^#, Zhijian Li, Chen Lin, Zhenfeng Zhu, Desen Sun, Rongpan Bai, Jun Qian, Xiangwei Gao*, Guangdi Chen*, Zhengping Xu*. Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis. Cell death and Disease. 2019, 10:127.

 2. Xnyuan Zhao^#, Yiming Liu^#, Ganlin Zhu, Yuanyuan Liang, Bo Liu, Yifan Wu, Muxi Han, Wenxing Sun, Yu Han, Gang Chen, Junkang Jiang*. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. Science of The Total Environment. 2019, 646(1): 1047-1055.

3. Xinyuan Zhao^#,*, Yifan Wu^#, Jinlong Li, Dongyu Li, Yang Jin, Piaoyu Zhu, Yingqi Liu, Yin Zhuang, Shali Yu, Weiming Cao, Haiyan Wei, Xiaoke Wang, Yu Han*, Gang Chen*. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology. 2019, 423: 42-53.

4. Xinyuan Zhao^#, Yang Jin^#, Lijia Yang, Zhengxing Hou, Yingqi Liu, Tianyu Sun, Jiaxin Pei, Jinlong Li, Chenjuan Yao, Xiaoke Wang*, Gang Chen*. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicology Letters. 2018, 296: 73-81.

5. Xinyuan Zhao, Fengjun Xing, Yewen Cong, Yin Zhuang, Muxi Han, Zhiqiang Wu, Shali Yu, Haiyan Wei, Xiaoke Wang*, Gang Chen*. Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells. The International Journal of Biochemistry and Cell Biology. 2017, 93(12): 32-40.

6. Xinyuan Zhao, Lifeng Yin, Yifan Wu, Muxi Han, Yin Zhuang, Yewen Cong, Yiming Liu, Gang Chen, Junkang Jiang*. Manganese induces neuroinflammation via NF-kB/ROS NLRP3 pathway in rat brain striatum and HAPI cells. Molecular & Cellular Toxicology. 2019, 15: 173-183.

7. Xinyuan Zhao^#, Tao Zhang^#, Yudan Zheng, Zixuan Zhao, Wenjie Ding, Ziyang Zhang, Zeyao Zhang, Rui Wang, Man Jiao, Lei Liu, Shali Yu, Xiaoke Wang, Rongrong Huang*, Qiyun Wu*. Gut Microbiota from Short-Chain Chlorinated Paraffin-exposed Mice promotes astrocyte activation by disrupting the intestinal tight junction via zonulin upregulation. Journal of agricultural and food chemistry. 2023. 235: 107537

通讯作者：

2024年：

1. Xinyi Ma, Mengna Jiang, Wenqian Ji, Mengjiao Yu, Can Tang, Kai Tian, Zhengnan Gao, Liling Su, Juan Tang*, Xinyuan Zhao*. The role and regulation of SIRT1 in pulmonary fibrosis. Molecular Biology Reports. 2024, 51: 338.

2. Hongliang Cui, Qiuru Huang, Jiaxin Li, Peiyao Zhou, Zihan Wang, Jiaying Cai, Chenrui Feng, Xiaonan Deng, Han Gu, Xuxin He, Juan Tang, Xiaoke Wang, Xinyuan Zhao*, Jun Yu*, Xia Chen*. Single-cell RNA sequencing analysis to evaluate antimony exposure effects on cell-lineage communications within the Drosophila testicular niche. Ecotoxicology and Environmental Safety. 2024, 115948.

3. Lei Liu, Chao Luo, Dongnan Zheng, Xuehai Wang, Rui Wang, Wenjie Ding, Chaoping Shen, Peng Xue, Shali Yu, Yifei Liu*, Xinyuan Zhao*. TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy. Food and Chemical Toxicology. 2024, 114378.

4. Yulan Cheng, Ziyang Zhang, Xiao Ma, Xuehai Wang, Lin Chen, Yonghua Luo, Xia Cao, Shali Yu, Xiangdong Wang*, Yali Cao*, Xinyuan Zhao*. The association between polycyclic aromatic hydrocarbons exposure and neuropsychiatric manifestations in perimenopausal women: A cross-sectional study. Journal of Affective Disorders. 2024. 344: 554-562.

2023年：

1. Juan Tang, Wenxia Bu, Wenxuan Hu, Zixuan Zhao, Lei Liu, Chao Luo, Rui Wang, Susu Fan, Shali Yu, Qiyun Wu *, Xiaoke Wang *, Xinyuan Zhao*. Ferroptosis is involved in sex-specific small intestinal toxicity in the offspring of adult mice exposed to polystyrene nanoplastics during pregnancy. ACS Nano. 2023.

2. Xiaoke Wang, Zixuan Zhao, Xin Wang, Wenxuan Hu, Chao Luo, Xiuyu Chu, Muzhou Qian, Rui Wang, Shali Yu, Qiyun Wu, Juan Tang *, Xinyuan Zhao*. Effects of polystyrene nanoplastic gestational exposure on mice. Chemosphere. 2023, 138255.

3. Mengjiao Yu, Wenqian Ji, Xu Yang, Kai Tian, Xinyi Ma, Shali Yu*, Lin Chen*, Xinyuan Zhao*. The role of m6A demethylases in lung cancer: diagnostic and therapeutic implications. Frontiers in immunology. 2023. 1279735.

4. Min Zhao, Jin Wan, Wenzhi Qin, Xin Huang,Guangdi Chen*, Xinyuan Zhao*. A machine learning-based diagnosis modelling of type 2 diabetes mellitus with environmental metal exposure. Computer methods and programs in biomedicine. 2023. 235: 107537.

5. Jun Yu, Yangbo Fu, Zhiran Li, Qiuru Huang, Juan Tang, Chi Sun, Peiyao Zhou, Lei He, Feiteng Sun, Xinmeng Cheng, Li Ji, Hao Yu, Yi Shi, Zhifeng Gu*, Fei Sun*, Xinyuan Zhao*. Single-cell RNA sequencing reveals cell landscape following antimony exposure during spermatogenesis in Drosophila testes. Cell death discovery. 2023. 9: 86.

6. Lingling Hong, Xuehai Wang, Weiming Cui, Fengxu Wang, Weiwei Shi, Shali Yu, Yonghua Luo*, Lixin Zhong*, Xinyuan Zhao*. Construction of a ferroptosis scoring system and identification of LINC01572 as a novel ferroptsis suppressor in lung adenocarcinoma. Frontiers in Pharmacology. 2023, 1098136.

7. Shuting Meng, Tianye Zhu, Zhiwei Fan, Yulan Cheng, Yanfeng Dong, Fengxu Wang, Xuehai Wang, Deping Dong*, Songtao Yuan*, Xinyuan Zhao*. Integrated signal-cell and transcriptome sequencing analysis develops a metastasis-based risk score system for prognosis and immunotherapy response in uveal melanoma. Frontiers in Pharmacology. 2023, 1138452.

8. Xiaoke Wang, Peiyao Zhou, Ziyang Zhang, Qiuru Huang, Xia Chen, Li Ji, Xinmeng Cheng, Yi Shi, Shali Yu, Juan Tang, Chi Sun*, Xinyuan Zhao*, Jun Yu*. A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis. Free Radical Biology and Medicine. 2023. 208: 418-429.

9. Yuanyuan Ma, Liang Yang, Mengna Jiang, Xinyuan Zhao*, Peng Xue*. Connecting Cryptococcal Meningitis and Gut Microbiome. International Journal of Molecular Sciences. 2023. 24: 13515.

10. Tingting Bian, Wenyi Zhang, Fengxu Wang, Xiuyu Chu, Xiaohui Pan, Junpu Ruan, Shali Yu, Lei Liu, Hui Sun, Hongmei Qiu, Ye Li, Juan Tang, Xinyuan Zhao*, Hongbing Zhang*. Identification of CLIC5 as a prognostic biomarker and correlated immumodulator for lung adenocarcinoma. Combinatorial chemistry & high throughput screening. 2023. 26: 2452-2468.

2022年：

1. Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang*, Xinyuan Zhao*. GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis. Ecotoxicology and Environmental Safety. 2022, 234: 113413. 

2. Xiangdong Wang, Rui Wang, Zeyao Zhang, Chao Luo, Zixuan Zhao, Junpu Ruan, Rongrong Huang, Hongbing Zhang, Qiyun Wu, Shali Yu, Juan Tang*, Xinyuan Zhao*. Level-specific associations of urinary antimony with cognitive function in US older adults from the National Health and Nutrition Examination Survey 2011-2014. BMC Geriatrics. 2022, 955979.

3. Wenyi Zhang, Pei Xiao, Jiayi Tang, Rui Wang, Xiangdong Wang, Fengxu Wang, Junpu Ruan, Shali Yu, Juan Tang, Rongrong Huang*, Xinyuan Zhao*. m6A Regulator-Mediated Tumor Infiltration and Methylation Modification in Cervical Cancer Microenvironment. Frontiers in Immunology. 2022, 888650. 

4. Wenjun Mao, Yun Cai, Danrong Chen, Guanyu Jiang, Yongrui  Xu, Ruo Chen, Fengxu Wang, Xuehai Wang, Mingfeng Zheng*, Xinyuan Zhao*, Jie Mei*. Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockage in non-small cell lung cancer. JCI insight, 2022, 7(18): e161940.

5. Xiangdong Wang, Pei Xiao, Rui Wang, Chao Luo, Zeyao Zhang, Qiyun Wu, Ye Li, Yali Zhang*, Hongbing Zhang*, Xinyuan Zhao*. Relationships between urinary metals concentions and cognitive performance among U.S. older people in NHANES 2011-2014. Frontiers in Public Health, 2022, 985127.

6. Wenjie Ding, Zixuan Zhao, Yudan Zheng, Rui Wang, Zeyao Zhang, Ziyang Zhang, Xiangdong Wang, Shali Yu, Lei Liu, Rongrong Huang, Xinyuan Zhao*, Qiyun Wu*. Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway. Ecotoxicology and Environmental Safety. 2022, 234: 113413.

7. Xuehai Wang, Fengxu Wang, Weiyi Xia, Siyuan Deng, Hongxiang Zhang, Xinyuan Zhao*. Facts and challenges of immunotherapy in triple-negative breast cancer. Tumor Discovery. 2022, 1(2). *corresponding author.

8. 李志杰，王瑞，刘蕾，于莎莉，江俊康，赵新元*. 抗增殖蛋白2在线粒体中的功能研究进展. 交通医学，2022，36（4）：340-343. (通讯作者)

9.赵子轩，王晓珂，朱颖，吴启运，赵新元*. POPs调控肝内脂肪酸从头合成相关分子的研究进展. 重庆医学，2022，51（14）：2495-2498. (通讯作者)

10.王瑞，刘蕾，邱红梅，赵新元*. 纳米二氧化硅影响自噬的机制及其生物学意义的研究进展. 重庆医学，2022，51（5）：874-879. (通讯作者)

2021年：

1. Shenya Xu, Zeyun Yang, Ye Zhi, Shali Yu, Tao Zhang, Junkang Jiang, Jun Tang, Hongsen He, Ming Lu, Xiaoke Wang*, Qiyun Wu*,Xinyuan Zhao*. The effects of antimony on Alzheimer’s disease-like pathological changes in mice brain. Science of the Total Environment. 2021,760: 143235.

2. Wenyi Zhang, Ting Chen, Jun Liu, Shali Yu, Lei Liu,Miaosen Zheng, Yifei Liu, Hongbing Zhang*, Tingting Bian*, Xinyuan Zhao*. RAB11F1P1: An Indicator for Tomor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics. Frontiers in Genetics. 2021, 12: 757169.

3. Yudan Zheng, Wenjie Ding, Tao Zhang, Zixuan Zhao, Rui Wang, Zhjie Li, Shali Yu, Jinlong Li, Xinyuan Zhao*, Qiyun Wu*. Antimony-induced astrocyte activation via mitogen-activated protein kinase activation-dependent CREB phosphorylation. Toxicology Letters. 2021, 352: 9-16.

4. Tao Zhang, Yudan Zheng , Man Jiao, Zhi Ye, Shenya Xu, Piaoyu Zhu, Xinyuan Zhao*, Qiyun Wu*. Nuclear Factor-kB Signaling Mediates Antimony-induced Astrocyte Activation. Biomedical and Environmental Sciences. 2021, 34(1): 29-39.

2020年：

1. Weiwei Shi, Yanfen Tang, Ye Zhi, Zhijie Li, Shali Yu, Junkang Jiang, Jinfeng Zhu, Jinlong Li, Junkang Jiang, Feng Wang*, Liling Su*, Xinyuan Zhao*. Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity. Science of The Total Environment. 2020, 737: 140252.

2. Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen*, Xinyuan Zhao*. p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation. Journal of nanobiotechnology. 2020, 18:77.

3. Ye Zhi, Chunhua Lu, Ganlin Zhu, Zhijie Li, Piaoyu Zhu, Yuting Liu, Weiwei Shi, Liling Su, Junkang Jiang*, Jianhua Qu*,Xinyuan Zhao*. Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain. Neurotoxicology. 2020, 81: 101-108.

4. Liling Su, Longtao Zhu, Zhenchao Liu, Jianyao Lou, Bing Han, Chen Lin, Dongyu Li, Jun Qian, Xinyuan Zhao*, Guangdi Chen*. The decreased permittivity of zebrafish embryos culture medium by magnetic fields did not affect early development of zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 193: 110350.

2019年：

1. Xiaoke Wang^#, Yuxue Yang^#,Piaoyu Zhu, Yifan Wu, Yang Jin, Shali Yu, Haiyan Wei, Muzhou Qian, Weiming Cao, Shenya Xu, Yingqi Liu, Gang Chen, Xinyuan Zhao*. Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. Environmental Pollution. 2019, 255:113366.

2. Xiaoke Wang^#, Piaoyu Zhu^#, Shenya Xu, Yuting Liu, Yang Jin, Shali Yu, Haiyan Wei, Jinlong Li, Qinglin Zhang, Takahiro Hasegawa, Chenjuan Yao, Hiroshi Yoshimura, Qiyun Wu, Xinyuan Zhao*. Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. The International Journal of Biochemistry and Cell Biology. 2019, 114:105561.

3. Ganlin Zhu^#, Yiming Liu^#, Ye Zhi, Yang Jin, Jinlong Li*, Weiwei Shi, Yuting Liu, Yu Han, Shali Yu, Junkang Jiang*, Xinyuan Zhao*. PKA- and Ca²⁺ -dependent p38MAPK/CREB activation protects against manganese-mediated neuronal apoptosis. Toxicology Letters. 2019, 309: 10-19. 

4. Changyue Wu, Kaizhi Yin, Yan Zhang, Man Jiao, Xinyuan Zhao*, Qiyun Wu*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway. Biomedical and Environmental Sciences. 2019, 32(4): 281-290.

5. Changyue Wu, Yifan Wu, Yang Jin, Piaoyu Zhu, Weiwei Shi, Jinlong Li, Qiyun Wu, Qinglin Zhang*, Yu Han*, Xinyuan Zhao*. Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis. RSC Advances. 2019, 9, 13855-13862.

6. Man Jiao^#, Kaizhi Yin^#, Tao Zhang, Changyue Wu, Yan Zhang, Xinyuan Zhao*, Qiyun Wu*. Effects of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death. Chemosphere. 2019, 226: 678-686. 

  科研项目：

 1. 国家自然科学基金面上项目，82173554，纳米二氧化硅通过下调SIRT1碱化肺泡上皮细胞溶酶体及诱导肺纤维化，2022/01-2025/12，55万元，在研，主持。

 2. 国家自然科学基金青年项目，81703255，肺泡上皮细胞p62聚集在超细颗粒物诱导肺纤维化中的作用及机制研究，2018/01-2020/12，20万，结题。

3. 江苏省自然科学基金面上项目，SIRT1降解在纳米二氧化硅诱导肺泡上皮细胞溶酶体碱化及肺纤维化中的作用和机制，2020/07-2023/06，10万，结题。

4. 江苏省高校“青蓝工程”，优秀青年骨干教师，2020/05-2023/05，4万，结题。

5. 南通市社会发展科技计划项目，MS12017014-8，靶向加快自噬流在颗粒物诱导肺损伤中的预防作用及机制研究，2017/07-2019/07，4万，结题。

6. 南通市基础科学研究项目，JC2019027，基于Wnt通路评估一种新神经毒物-锑的阿尔茨海默病致病风险， 2019.07-2021.06，3.0万，结题。

7. 自噬在锑引起A549细胞损伤中的作用及机制，南通大学引进人才项目，2017/04-2019/04，4万，结题。

8. 校级教改课题，基于实践技能导向的《环境卫生学》实验教学改革研究，2018/09-2020/06，0.3万，结题。

9.南通大学大型仪器设备开放基金，2020年，0.5万，结题。

获得奖项：

1.大气污染物经呼吸道暴露的损伤效应及机制（2021年），江苏省高校科学技术研究成果奖，三等奖，第一完成人。

2. 第十八届“挑战杯”全国大学生课外学术科技作品竞赛国赛一等奖（2023年），第一指导教师。

3. 2019年度南通市科技创业大赛，大学生团队二等奖，指导老师。